Some users have success replacing the FTDI driver with a generic WinUSB driver using :
: When your OP-COM 1.99 connects for the first time on Windows 10, accompanied by the familiar click of relays in the interface, you’ll know the struggle was worth it. opcom 1.99 drivers windows 10
: This setting resets after every shutdown. On each use of OP-COM 1.99, you must reboot using this method unless you permanently disable signature enforcement (not recommended for daily use). Some users have success replacing the FTDI driver
The primary issue with Windows 10 is that these devices often use that require specific, often unsigned drivers, which Windows 10 blocks by default for security. Step 1: Where to Download Drivers often unsigned drivers